Tuesday, January 25, 2011

Medvedev blames security lapse for Moscow blast

MOSCOW (Reuters) – President Dmitry Medvedev placed the blame on Tuesday on a lapse in security for allowing a suspected suicide bomber to kill at least 35 people and wound scores at Russia's busiest airport.
There was no immediate claim of responsibility for Monday's attack at Moscow's Domodedovo airport, but the action bore hallmarks of militants fighting for an Islamist state in the North Caucasus region on Russia's southern frontier.
"It's obviously a terrorist act that was planned well in advance in order to cause the deaths of as many people as possible," said President Dmitry Medvedev on Tuesday.
"What happened shows that there were clear security violations," he said. The attacker evaded security to carry the explosives into the airport's arrival hall.                                                                                                

North Caucasus rebels have threatened attacks against cities and economic targets in the run-up to parliamentary elections this year and 2012 presidential polls. The choice of Domodedovo, resulting in the deaths of several foreigners, suggested the attackers sought to raise uncertainty beyond Russia's borders.
Russia is due to host the 2014 Winter Olympics in Sochi, on the edge of the Caucasus, which some rebels consider part of the territory they aim to include in an Islamic state.
Medvedev, due to open the World Economic Forum on Wednesday, delayed his departure to the Swiss city of Davos and was due to hold a meeting with his security services on Tuesday. On Monday he vowed to track down and punish those behind the blast.
Russian media reports gave conflicting information about the identity of the suspected bomber, or whether there might have been more than one attacker.
Prime Minister Vladimir Putin, the more powerful in Russia's 'tandem' political leadership, built his early reputation as a strong leader by launching a war in late 1999 to crush a rebel government in the Northern Caucasus's Chechnya region. That campaign achieved its immediate aim, but since then, insurgency has spread to neighboring Ingushetia and Dagestan.
It has also assumed a more ruthless edge, spawning hardline factions difficult to monitor. Putin and Medvedev have said they would crush the rebel movements, but their control in the region has sometimes looked tenuous.
"These would likely (but not necessarily) be Islamists from the Northern Caucasus. If so, yet another example of the proposition that success in Chechnya has generated a more diffuse and dangerous threat," said Neil MacFarlane, Professor of International Relations, St. Anne's College, Oxford.
"The consequences? More abuse of people of Caucasian origin in Moscow and elsewhere in Russia...more intense military/police response in the region will make the problem more severe rather than less, because of the methods that are likely to be employed, and the obligation to revenge."                                                                         
NATIONALIST VIOLENCE
The spread of violence from the North Caucasus, where it is fed by a cocktail of corruption, poverty and clan rivalries as well as religious radicalism, fans Russian nationalist militancy in the heartland.
Tensions between ethnic Russians and the 20 million Muslims who make up one seventh of Russia's population flared dramatically last month in a string of clashes, which involved thousands of Russian nationalists who attacked passersby of non-Slavic appearance, many of them from the North Caucasus.
The incidents caused alarm in the Kremlin.
Analysts said such attacks, if sustained, could raise doubts over foreign involvement in the Russian economy, although there were no signs of any serious reaction in Russian markets to Monday's attack.
The prosecutor's office said the attack, the largest since twin suicide bombings on the Moscow metro rocked the Russian heartland in March, "was most likely carried out by a suicide bomber".
Moscow suffered its worst attack in six years in March last year, when two female suicide bombers from Dagestan set off explosives in the metro, killing 40 people.
The worst incident involving North Caucasus rebels took place in 2004 when militants seized control of a school in the town of Beslan. When Russian troops stormed the building in an attempt to end a siege, 331 hostages, half of them children, were killed.
(Writing by Thomas Grove and Amie Ferris-Rotman, additional reporting by Alexei Anishchuk, Thomas Grove, Amie Ferris-Rotman, Guy Faulconbridge, Steve Gutterman and Alissa de Carbonnel, Editing by Peter Gra


ff)
 

A new way to kill cancer cells

A new way to kill cancer cells

By Christina Hernandez | Jul 22, 2010 |
Unlike normal cells, cancer cells can grow and age without dying — one of the reasons they’re so dangerous. But researchers at Washington State University have developed a way to help cancer cells age and die, which could lead to treatment that slows or stops tumor growth.
The research, by Weihang Chai of the Washington State University School of Molecular Biosciences and colleagues, was reported in the current issue of The EMBO Journal. It was funded in part by the National Institutes of Health and the American Cancer Society. I spoke with Chai this week.
How do cancer cells differ from normal cells in terms of their mortality?                                                                                                                                              


The big difference between cancer cells and normal cells is that cancer cells can divide forever and live forever. We call this immortality. The normal cells will divide for a number of divisions and then stop growing. They get old and either they die or they sit there and do nothing. They are mortal.
Cancer cells have a way to maintain their telomeres. Their telomeres don’t get shortened. Each time the normal cells divide they lose some telomere DNA sequences. Eventually when the telomere DNA becomes too short, they stop growing. There are also other factors contributing to the mortality of normal cells.
Is the immortality of cancer cells what makes them so dangerous?
The cancer cells divide uncontrollably. Then you have more and more cancer cells in one location of your body that can invade the surrounding tissues and disrupt the function of the normal tissues. They form the tumor. The cancer cells also can circulate around your body and get into other places and form tumors in the new locations. This is in part due to the immortality of cancer cells. They don’t die. Normal cells grow at one location and at some point they will stop.
Talk about your work on making cancer cells “more mortal.”
The majority of the cancer cells, about 90 percent, they activate a molecule called telomerase. Telomerase is usually not activated in normal cells, except for in stem cells. In cancer cells, the telomerase is active. The function of telomerase is to add telomere DNA at the short telomeres. That’s why cancer cells don’t lose their telomeres. In the normal cells telomerase is off, so there is no way to maintain their telomere length. [This would suggest that] if you kill the telomerase in cancer cells, the telomere [would gradually shorten] and the cancer cells will die.                                                                                     
 


However, recently we have found that the telomerase extends just one strand of DNA. The other strand should be synthesized by other molecules, other proteins. We found the molecule that’s responsible for synthesizing the other strand. If you block the function of this molecule, then the telomere cannot be maintained properly, so the cell also just stops growing.
We’re just at this stage now. We don’t know how this whole thing works. We’re working on that and hopefully in the future we can design a way to target this process, not directly target telomerase but target the synthesis of the other strand. That’s another way of stopping the cancer cell’s growth.
What’s the next step to move this research forward?
The next step will be to find out how this whole thing is regulated. We’d like to know whether in normal cells the synthesis of the other strand also occurs because you want to specifically target the cancer cells. If this does exist, [we want to know] whether the same process is regulated by different pathways in normal cells compared to cancer cells. Our ultimate goal is to see if there are any specific targets we can inhibit in the cancer cells.
Could this eventually become a treatment for people with cancer?
We hope so. It’s going to be a long way. That probably will involve some other research groups, not just our group.

Monday, January 24, 2011

Fitness legend Jack LaLanne dead at 96

Fitness guru Jack LaLanne died Sunday of respiratory failure due to pneumonia Sunday afternoon at his home in central California, his longtime agent said.
“I have not only lost my husband and a great American icon, but the best friend and most loving partner anyone could ever hope for,” Elaine LaLanne, LaLanne’s wife of 51 years and a frequent partner in his television appearances, said in a written statement.
LaLanne had a television show from the 1950s to the 1970s in which he demonstrated exercises using no special equipment. He continued to be an inspiration to Americans until his death. He founded a chain of fitness studios and late in his life he promoted Jack LaLanne’s Power Juicer.

Wednesday, December 29, 2010

Sugarloaf Chairlift AccidentSugarloaf Chairlift Accident

Sugarloaf Chairlift Accident

Tuesday December 28, 2010
There is word out of Maine of a cable derailment at Sugarloaf in Maine. AP is quoting Sugarloaf spokesman Ethan Austin as saying there have been injuries when several chairs on that lift came down. The chairlift is being evacuated and injuries are being assessed and responded to by the Ski Patrol.
In a 1:00 ET Press Release Ethan Austin says:
"Today, at approximately 10:30 am, the Spillway East Chairlift experienced a rope derailment.  At this time, we have 6 injured guests who have been treated and transported from the mountain. All available mountain safety personnel are at the scene.  The injured parties have been taken off the mountain.  Additionally, the remaining guests on the lift have all been successfully evacuated from the lift. As of now, the cause of the incident is still unknown and is under investigation."